Endocrine Abstracts

Introduction: Lymphocytic hypophysitis (LH) is a rare condition that has been increasingly recognised. We studied the natural history and current management of patients with lymphocytic hypophysitis.Methods: We performed a multi-centre retrospective review of all patients that either had histologically proven disease or a strong clinical suspicion for its presence, diagnosed from 2000 onwards. Cases of secondary hypophysitis or granulomatous or xanthomat...

A 32-year-old female presented with a 6-week history of worsening headaches associated with bitemporal visual field defects. An urgent MR scan demonstrated a sizeable pituitary lesion with chiasmal compression and suprasellar extension. Endocrine tests revealed hyperprolactinaemia (2550 mU/l) with hypocortisolaemia (<37 nmol/l). Cabergoline and hydrocortisone replacement were initiated. Unfortunately, 24 h later her visual fields deteriorated further and the patient underw...

Case history: A 50-year-old lady presented with blurred vision in her left eye. She was clinically eupituitary. Visual field testing confirmed a bitemporal field deficit. MRI pituitary showed a pituitary macroadenoma occupying part of the sphenoid fossa and causing significant optic chiasmal compression. The lesion was extending across the left carotid loop, with a part of the lesion extending and compressing the medial aspect of the left temporal lobe. She was found to be hyp...

Aim: To find out all Acromegalic patients above the age of 40 years had their colonoscopic screening or not.Reason for colonoscopy screening: There is 13 to 14 fold increased risk of colorectal cancer in Acromegaly patients and 2.5 fold increase in mortality from Colonic cancer.Standards: i) Patientts with acromegaly should be offered regular colonoscopy from the age of 40 years.ii) ...

Introduction: Prolonged use of topical corticosteroids causes systemic adverse effects including Cushing’s syndrome and hypothalamic–pituitary–adrenal (HPA) axis suppression, which is less common than that of the oral or parenteral route.History: A 31-year-old female patient was referred from the dermatology clinic with symptoms and signs consistent with Cushing’s syndrome. She has been treated for psoriasis with a prolonged course of...

We present a 35-year-old male who was incidentally found to have a large macroadenoma when he presented with left sided weakness three months ago. He had no headaches or visual disturbances. His prolactin at presentation was >100 000 mU/l (86–324 mU/l). Magnetic resonance imaging confirmed an invasive macroadenoma. His Humphrey’s visual field tests were normal.Rest of the endocrine profile revealed a normal T4 of 14.3 (12–22...

A 37 year old male presented with visual problems in June 2006.He gave a history of double vision for 18 months and denied headaches.On examination his Glasgow coma score was 15/15, pupils were equal and reactive to light. Visual acuity; right eye - 6/6, left eye- 6/60. Visual field testing showed a temporal field defect in the right eye and poor vision in the left eye.MRI brain scan showed a very large, fair...

A 24 year old male presented to his GP with rapid growth in height and joint pain and a physiotherapist suggested that he could have late stage gigantism. Upon presentation he had recently grown from 208 cm to 216 cm tall during a short number of months. His symptoms included fatigue, sweating, oily skin and deepening of his voice. Of note he had prognathism, frontal bossing, macroglossia, broadening of his nose and significant interdental spacing. His mother is 165 cm tall, h...

Objective: To describe the experience of pituitary apoplexy from a single-centre modern series.Methods: We retrospectively reviewed the case notes of patients presenting to Salford Royal NHS Foundation Trust between February 2005 and April 2014 with pituitary apoplexy.Results: A total of 32 cases (20 males) presenting with classical apoplexy were identified, with a mean age at presentation of 54 years (range 22–88 years). 11 p...

A 60-year-old female was referred to the department in October 2010 after a CT thorax revealed an incidental finding of a right adrenal nodule. On questioning, the patient reported some sweats but otherwise no other symptoms of hormonal excess. Adrenal functional studies were normal and it was therefore decided that the patient should have a repeat CT scan in 6 months. Repeat CT adrenal glands in April 2011 did not show any changes to the size of the nodule but gave indetermin...